Likewise the pre-op patient who told me he was allergic to epinephrine... "What happens when you are given epi?" "It makes my heart race!" Anesthesia and I had a good laugh about it!
Drugs associated with malignant hyperthermia susceptibility, a critical emergency condition whenever it occurs: "inhaled general anesthetics such as desflurane, enflurane, ether, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholine (warning) All other anesthetic agents not in the above categories of volatile anesthetic agents and depolarizing muscle relaxants are considered safe." While rare, but life-threatening reaction cannot be predicted ahead of time until the patient is undergoing its use. "...[MHS] is inherited in an autosomal dominant manner. Most individuals diagnosed with MHS have a parent with MHS; however, the parent may not have experienced an episode of MH." When your patient tells you they're allergic to sux, the next question is, "who else in your family sux?" (Urge other immediate family members to get tested.) PSA your friendly pharmacist
Do you think the patient actually had pseudocholinesterase deficiency and was just not distinguishing between the prolonged paralysis from that and the normal effect of the drug?
As someone with an inherited neuromuscular disorder which causes susceptibility to malignant hyperthermia, it might be a good idea to ask more questions when a patient says they are "allergic" to succinylcholine. Patients don't speak in medical jargon, and when they do physicians are immediately suspicious. I've experienced MH during surgery, as did my older brother. He barely survived (13 weeks in ICU, three more weeks in hospital and three months in rehab) and he never walked again.
That sucks.
ReplyDeleteLikewise the pre-op patient who told me he was allergic to epinephrine...
ReplyDelete"What happens when you are given epi?"
"It makes my heart race!"
Anesthesia and I had a good laugh about it!
Well . . . .
ReplyDeleteDefine "Allergic".
ReplyDeletei guess the next question, after a smothered chuckle, was "and how long did you stop breathing for"?
ReplyDeleteyep, you did. everyone who takes it stops breathing. That is what it is for
ReplyDeleteMs Succinct, I think
ReplyDeleteI saw this in a patient chart once:
ReplyDeleteAllergies: ethyl alcohol
Reaction: syncope
Me: What are you allergic to?
ReplyDeleteHer: Morphine
Me: What happens when you take morphine?
Her: I feel lightheaded
Me: ...
A vet tech I briefly worked with told us her dog couldn't tolerate dexmedetomidine (alpha-2 agonist) because he got bradycardic. No shit, Sherlock.
ReplyDeleteDrugs associated with malignant hyperthermia susceptibility, a critical emergency condition whenever it occurs: "inhaled general anesthetics such as desflurane, enflurane, ether, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholine (warning) All other anesthetic agents not in the above categories of volatile anesthetic agents and depolarizing muscle relaxants are considered safe." While rare, but life-threatening reaction cannot be predicted ahead of time until the patient is undergoing its use. "...[MHS] is inherited in an autosomal dominant manner. Most individuals diagnosed with MHS have a parent with MHS; however, the parent may not have experienced an episode of MH." When your patient tells you they're allergic to sux, the next question is, "who else in your family sux?" (Urge other immediate family members to get tested.) PSA your friendly pharmacist
ReplyDeleteApologies ... while most folks will stop breathing with succinylcholine, it really sucks to have an allergy resulting in malignant hyperthermia.
ReplyDeleteDo you think the patient actually had pseudocholinesterase deficiency and was just not distinguishing between the prolonged paralysis from that and the normal effect of the drug?
ReplyDeleteI am breathlessly awaiting the outcome of this story.
ReplyDeleteAs someone with an inherited neuromuscular disorder which causes susceptibility to malignant hyperthermia, it might be a good idea to ask more questions when a patient says they are "allergic" to succinylcholine. Patients don't speak in medical jargon, and when they do physicians are immediately suspicious. I've experienced MH during surgery, as did my older brother. He barely survived (13 weeks in ICU, three more weeks in hospital and three months in rehab) and he never walked again.
ReplyDelete