tag:blogger.com,1999:blog-5883634615775822475.post5341374891607918609..comments2024-03-18T09:00:31.992-04:00Comments on Doctor Grumpy in the House: Survey funGrumpy, M.D.http://www.blogger.com/profile/09858110332436246760noreply@blogger.comBlogger21125tag:blogger.com,1999:blog-5883634615775822475.post-40979844503731147372010-06-24T21:52:39.468-04:002010-06-24T21:52:39.468-04:00check that- it is phase i, not stage i. sorry, dr....check that- it is phase i, not stage i. sorry, dr.g.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-73715345649071721432010-06-24T19:31:04.019-04:002010-06-24T19:31:04.019-04:00safety in humans trials = stage isafety in humans trials = stage iAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-16169451691866082442010-06-24T14:43:46.536-04:002010-06-24T14:43:46.536-04:00Ben, the two of us need look no more, we both foun...Ben, the two of us need look no more, we both found what we were looking for...silly dog volunteers. <br /><br />At least rats wouldn't be out of a job as guide 'rats' if they went blind.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-23458099496676939952010-06-24T13:05:43.936-04:002010-06-24T13:05:43.936-04:00>>they are trying to decide if they should i...>>they are trying to decide if they should invest in further development and testing, if most will never prescribe based on the dog data, the drug is dead>><br /><br />I gathered, but don't human drugs have to undergo first safety (in humans), then efficacy (again, in humans) trials prior to approval?<br /><br />That's after the drugs have been proven reasonably safe in non-human research subjects, of course.Outridernoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-55039605962336605332010-06-24T12:03:05.155-04:002010-06-24T12:03:05.155-04:00who cares-effect or affect? We all knew what he wa...who cares-effect or affect? We all knew what he was saying.robomodA. Texannoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-32604949881617979512010-06-24T08:38:32.267-04:002010-06-24T08:38:32.267-04:00Sorry gang, the effect/affect error was mine. I fi...Sorry gang, the effect/affect error was mine. I fixed it.Grumpy, M.D.https://www.blogger.com/profile/09858110332436246760noreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-62618377668405688742010-06-24T07:40:02.670-04:002010-06-24T07:40:02.670-04:00I am not sure how that error was the fault of the ...I am not sure how that error was the fault of the survey writer or copywriter, since it was a verbal survey.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-15769317969670881652010-06-24T04:33:28.648-04:002010-06-24T04:33:28.648-04:00outrider- they are trying to decide if they should...outrider- they are trying to decide if they should invest in further development and testing, if most will never prescribe based on the dog data, the drug is dead.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-85898610941401148812010-06-24T03:54:42.107-04:002010-06-24T03:54:42.107-04:00The short answer is: rats are not dogs, and dogs ...The short answer is: rats are not dogs, and dogs are not humans.<br /><br />There isn't room enough in this comment box for the long answer, but what a useless, irrelevant question to ask a physician.<br /><br />This would be a valid question for a survey targeting veterinarians, as there are many drugs that cause serious side effects in one species but not another. For example, chloramphenicol... great stuff, but not for humans.Outridernoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-55174476645524312242010-06-24T03:26:32.651-04:002010-06-24T03:26:32.651-04:00628pm- michael vick et al628pm- michael vick et alAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-30597308560313174352010-06-24T00:05:15.136-04:002010-06-24T00:05:15.136-04:00"I would not prescribe the drug to dogs."..."I would not prescribe the drug to dogs."<br /><br />Thank you, I'm here all week.Chrishttps://www.blogger.com/profile/14794712479594188124noreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-57454970961776515722010-06-23T23:53:31.355-04:002010-06-23T23:53:31.355-04:00Bless you!
On this day (and many days) when I nee...Bless you!<br /><br />On this day (and many days) when I need a considerable dose of reality plus laughter, I get you.<br /><br />You rock!A Doc 2 Behttps://www.blogger.com/profile/10310878304648897210noreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-72104730425432063152010-06-23T19:28:55.946-04:002010-06-23T19:28:55.946-04:00Just what I was thinking Old MD Girl...I was also ...Just what I was thinking Old MD Girl...I was also thinking 'where did they find psychotic dogs?'Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-82414378389720775412010-06-23T14:49:37.276-04:002010-06-23T14:49:37.276-04:00if the drug really has promise it may be time for ...if the drug really has promise it may be time for stage i testing with appropriate informed consentAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-81660653349315579012010-06-23T13:54:00.821-04:002010-06-23T13:54:00.821-04:00Wait, I thought you had an appointment made with a...Wait, I thought you had an appointment made with a dog a while back?ERPhttps://www.blogger.com/profile/15973334581468131595noreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-8953854419294065182010-06-23T13:10:13.992-04:002010-06-23T13:10:13.992-04:00Seroquel?Seroquel?OMDGhttps://www.blogger.com/profile/17937425894428802591noreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-50876024406146117662010-06-23T12:52:00.855-04:002010-06-23T12:52:00.855-04:00Let's see if cladistics can address the issue:...Let's see if cladistics can address the issue: Primates go back to the Cretaceous, rodents go back to the early Tertiary, and dogs show up around the mid-Tertiary. Therefore, dogs are more derived than rats and people, and whatever reactions they have to a drug might be the result of traits not shared with rodents and people.David N. Brownhttps://www.blogger.com/profile/03296102565243287206noreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-90029075359365997592010-06-23T12:29:53.806-04:002010-06-23T12:29:53.806-04:00Death to all copywriters who cannot use affect and...Death to all copywriters who cannot use affect and effect appropriately! You idiots, you have one job to do!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-25183304377056193122010-06-23T11:57:10.134-04:002010-06-23T11:57:10.134-04:00Uhhhh i'd not prescribe the drug because isn&#...Uhhhh i'd not prescribe the drug because isn't testing on dogs illegal?Angelahttps://www.blogger.com/profile/08071125157930976758noreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-55345183263602980862010-06-23T11:44:10.438-04:002010-06-23T11:44:10.438-04:00It's *affect*, anyways, to boot. Well done, s...It's *affect*, anyways, to boot. Well done, survey writer.... not.Sunnynoreply@blogger.comtag:blogger.com,1999:blog-5883634615775822475.post-22164337190228623752010-06-23T11:33:21.703-04:002010-06-23T11:33:21.703-04:00Dude, You gotta know how to evaluate all that valu...Dude, You gotta know how to evaluate all that valuable scientific information....Christie Crittershttps://www.blogger.com/profile/17409348100826092353noreply@blogger.com